Cryo-electron microscopy structure of the budding yeast telomerase holoenzyme - PubMed
3 hours ago
- #cryo-EM
- #telomerase
- #yeast
- The cryo-electron microscopy structure of the budding yeast telomerase holoenzyme reveals substantial divergence from ciliate and vertebrate counterparts.
- A stable core is formed by telomerase RNA TLC1, the three Est proteins (Est1, Est2, Est3), and the Pop1/Pop6/Pop7 complex, with TLC1, Est3, and Pop1/6/7 playing critical roles in assembly.
- A zinc finger (ZnF) motif in the TERT subunit Est2 was identified as crucial for telomerase function, and structure prediction suggests ZnFs may be present in TERT across diverse species.