The Conjugated Bile Acids Profile Suggests a Novel Liver-Muscle Axis Associated With Sarcopenia in Chronic Liver Disease - PubMed
3 hours ago
- #bile acids
- #chronic liver disease
- #sarcopenia
- Elevated serum conjugated bile acids (C-BAs) are associated with sarcopenia in chronic liver disease.
- C-BA levels correlate negatively with muscle area loss and are linked to systemic inflammation.
- Muscle biopsies reveal a shift from fast-twitch to slow-twitch fiber markers and local inflammation.
- In vitro validation shows glyco-C-BAs reduce the fast-twitch marker MYH4 in myotubes.
- C-BAs may serve as a liver-derived humoral factor and a potential therapeutic target for sarcopenia.