From Imaging to Molecular Pathways: A Comprehensive Narrative Review of the Distinctive Landscape of Secretory Meningioma - PubMed

3 hours ago

Secretory meningioma (SM) is a rare WHO grade I variant, making up about 1-3% of meningioma cases.
Despite its benign classification, SM often causes excessive peritumoral brain edema (PTBE), leading to significant morbidity.
Key diagnostic features include pseudopsammoma bodies, strong immunoreactivity for CEA and EMA, and specific KLF4 K409Q and TRAF7 mutations.
Radiological indicators such as FLAIR hyperintensity and increased ADC values are critical for differentiating SM from higher-grade meningiomas.
Gross total surgical resection is the standard treatment, but severe postoperative edema complicates perioperative management and may require additional therapies.
Accurate identification of SM as a distinct subtype is essential for proper diagnosis, prognosis, and treatment planning.

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