Gut microbiota immaturity with DL-endopeptidase deficiency links antibiotic use to preterm late-onset sepsis - PubMed
3 hours ago
- #late-onset sepsis
- #preterm infants
- #gut microbiota
- Early antibiotic exposure increases late-onset sepsis (LOS) risk in preterm infants, potentially via gut dysbiosis.
- Analysis of 4,938 fecal samples from preterm infants in China, the US, and the UK showed differential gut microbiota development.
- Delayed microbiota maturation correlated with over one-third of LOS risk linked to early antibiotic exposure.
- Deficiency of bacterial DL-endopeptidase was a hallmark of delayed microbiota development and elevated LOS risk.
- Supplementation with DL-endopeptidase-producing bacteria (Enterococcus faecium or Limosilactobacillus reuteri) activated NOD2 via MDP, regulated macrophage function, and reduced inflammation.
- A pilot trial showed L. reuteri supplementation enhanced fecal NOD2 activation in preterm infants.
- Findings suggest microbiota immaturity and reduced DL-endopeptidase activity link antibiotic exposure to LOS risk.