PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein - PubMed
7 hours ago
- #coronavirus
- #autophagy
- #viral replication
- PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein.
- CCDC50 restricts PDCoV replication by recognizing and targeting the viral envelope (E) protein for autophagic degradation.
- NSP5-mediated cleavage of CCDC50 at glutamine 171 disrupts its interaction with LC3 and ubiquitin, neutralizing its antiviral function.
- This cleavage mechanism is conserved among coronaviruses, including PEDV, TGEV, and SARS-CoV-2.
- The study reveals a common viral strategy to subvert host autophagy defenses.