Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe - PubMed
3 hours ago
- #transcription factors
- #Drosophila
- #neurodevelopment
- The study identifies how spatial, temporal, and Notch mechanisms integrate to specify neuronal cell fate in the Drosophila optic lobe medulla.
- Terminal selectors, which are transcription factors, maintain neuronal identity by controlling type-specific features throughout development and into adulthood.
- Using single-cell mRNA sequencing, researchers mapped the spatial origins of medulla neurons to correlate patterning information with terminal selector expression.
- Findings suggest that different subsets of patterning information regulate individual terminal selectors and specific modules of neuronal features, such as neurotransmitter identity.