Biomarkers and clinical factors associated with sepsis-induced coagulopathy: A systematic review and meta-analysis - PubMed
5 hours ago
- #meta-analysis
- #sepsis-induced coagulopathy
- #biomarkers
- Sepsis-induced coagulopathy (SIC) is a life-threatening complication affecting patient prognosis.
- A systematic review and meta-analysis included 34 studies with 37,459 patients to evaluate predictive factors.
- Key biomarkers associated with SIC include glycocalyx degradation (strongest predictor), reduced fibrinogen and albumin, neutrophil extracellular traps, increased microparticles, elevated lactate and thrombomodulin, procalcitonin, APACHE II score, and C-reactive protein.
- The findings are statistical associations, not causal links, and further trials are needed to confirm clinical utility for early risk identification.