Parvalbumin-positive neurons in the medial septum participate in the formation of hippocampal-dependent spatial memory - PubMed
3 hours ago
- #memory
- #neuroscience
- #hippocampus
- Parvalbumin-positive neurons in the medial septum are involved in hippocampal-dependent spatial memory formation.
- Acute sleep deprivation in male mice was used to create an object-place recognition impairment model.
- These neurons regulate object-location memory specificity during encoding by influencing hippocampal place cell activity.
- In vivo electrophysiology and optogenetics revealed their role in object-place recognition during memory encoding.
- Activation of medial septal parvalbumin-positive neurons can rescue object-place recognition impairments.
- The study suggests a causal role for these neurons in object-place recognition memory.