A novel microprotein L3EMP triggers lung adenocarcinoma progression by catalysing the deubiquitination of SIRT1 - PubMed
6 hours ago
- #Microprotein L3EMP
- #Lung Adenocarcinoma
- #Deubiquitination
- L3EMP is a novel microprotein encoded by LINC00973 that is overexpressed in lung adenocarcinoma (LUAD) and correlates with poor prognosis.
- L3EMP promotes LUAD progression by stabilizing SIRT1 through USP22-mediated deubiquitination, activating the AKT/ERK signaling pathway via a YY1 positive feedback loop.
- L3EMP knockout suppresses tumor growth in PDX models, and synthetic L3EMP peptide acts as a neoantigen to enhance anti-tumor immunity.
- Deletion of L3EMP synergizes with B7-H3 CAR-T therapy by activating the IFN-γ pathway, suggesting a promising combination strategy for LUAD treatment.