Clinical Characterization of Atypical Diabetes: Insights from the GENEPEDIAB Study into the Spectrum Between Type 1 and Monogenic Diabetes - PubMed
3 hours ago
- #genetics
- #diabetes
- #pediatrics
- The GENEPEDIAB study explores the phenotypic continuum between Type 1 Diabetes (T1D) and monogenic diabetes, including MODY.
- A gradient in glycemic parameters was observed across T1D, atypical diabetes (Adia), and MODY patients, with T1D patients showing the poorest glycemic control.
- Stratification of Adia patients by DIAMODIA criteria supported the phenotypic gradient, with glycemic measures and correspondence analysis highlighting differences.
- Genetic analyses in the Adia cohort revealed rare variants in diabetes-related genes but no uniform causative variant.
- The study concludes that atypical diabetes occupies an intermediate position in the spectrum between T1D and monogenic diabetes in pediatric patients.