CD138 expression in the endometrium associates with endometrial timing and inflammatory status but not microbiota composition - PubMed
4 hours ago
- #endometrium
- #microbiome
- #recurrent miscarriage
- CD138 expression in the endometrium is cycle-dependent and linked to impaired luteal phase endometrial timing but not microbiota composition.
- Three patterns of CD138 immunoreactivity were identified: membranous punctate, diffuse, and mixed staining.
- Stromal CD138 expression is high in proliferative endometrium and declines post-ovulation.
- Diffuse stromal CD138 staining correlates with earlier endometrial histological dating and lower molecular timing ratios.
- No significant difference in vaginal, ectocervical, or endometrial microbiota was found with CD138 expression.
- Inverse correlation between stromal CD138 immunoreactivity and levels of IL-10, TNF-α, and VEGF was observed.
- Study challenges the link between CD138+ chronic endometritis (CE) and recurrent pregnancy loss (RPL).
- CD138-based CE testing and treatment should not be performed outside research contexts.