Comparative proteomic profiling of receptor kinase signaling reveals key trafficking components enforcing plant stomatal development - PubMed
3 hours ago
- #receptor kinase
- #plant development
- #proteomics
- The study uses comparative proteomic profiling to explore the ERECTA receptor kinase signaling in plant stomatal development.
- ER-AP and TurboID-based proximity labeling identified interactome and proximitome, revealing components like TOO MANY MOUTHS and endosomal trafficking machinery.
- PICALMs interact with ERECTA to regulate its internalization via clathrin-mediated endocytosis, with mutations impairing endocytosis and causing stomatal clustering.
- Timely removal of receptor kinase through endocytosis is crucial for active signal transduction and proper stomatal patterning.
- The research provides a proteomic atlas of the ERECTA signaling network, highlighting key trafficking components in plant development.