"Bottlebrush" particles deliver chemotherapy payloads directly to cancer cells
5 hours ago
- #cancer-treatment
- #drug-delivery
- #nanotechnology
- MIT chemists developed bottlebrush-shaped particles to deliver chemotherapy drugs directly to tumor cells.
- Each particle contains an antibody targeting a specific tumor protein, carrying dozens to hundreds of drug molecules.
- In mouse models, the treatment eliminated most breast and ovarian tumors.
- The technology allows for less potent drugs and potential combination therapies.
- The particles outperformed FDA-approved antibody-drug conjugates (ADCs) in efficacy.
- Future modifications could target other cancers and include immunotherapy drugs.