Exploring the association between Frailty Index and Knee osteoarthritis in middle-aged and older Chinese adults: A cross-sectional analysis of data from the China Health and Retirement Longitudinal St
7 hours ago
- #Knee Osteoarthritis
- #Geriatric Health
- #Frailty Index
- Study examines link between Frailty Index (FI) and symptomatic Knee Osteoarthritis (KOA) in Chinese adults aged 45+ using CHARLS data.
- Results show significant positive association (OR 3.63), with a logarithmic non-linear relationship identified via restricted cubic splines.
- Subgroup analyses indicate interactions by gender, education, residence, alcohol, hypertension, and dyslipidemia.
- Random Forest machine learning model performed best (AUC 0.90) for predicting KOA, based on calibration and decision curve analysis.
- Findings suggest higher frailty scores correlate with increased KOA prevalence, highlighting a potential inflection point for targeted interventions.