Noninvasive Differentiation of Indolent from Aggressive Renal Neoplasms with MR Fingerprinting Combined with Diffusion/Perfusion MRI - PubMed
a day ago
- #Noninvasive Imaging
- #Renal Neoplasms
- #MRI
- Noninvasive differentiation of indolent from aggressive renal neoplasms using MR fingerprinting (MRF) combined with diffusion/perfusion MRI.
- Study evaluates kidney MRF with diffusion-weighted imaging and arterial spin labeling (ASL) MRI for tumor characterization.
- Participants with suspected renal cell carcinoma (RCC) were recruited, with histopathologic grading as the reference standard.
- Tumors classified as indolent (low-grade/benign) or aggressive (high-grade/unclassified RCCs).
- MRF-derived T2 showed significant difference between indolent (86 msec ± 22) and aggressive (61 msec ± 14) tumors (P = .005).
- No significant differences observed in T1, ADC, or RBF between groups (P > .05).
- T2 alone achieved an AUC of 0.83 for differentiation, while combined T1 and T2 improved AUC to 0.89.
- Kidney MRF enables rapid (15 seconds per section), multiparametric quantitative imaging without contrast material.