ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway - PubMed
8 hours ago
- #Acute Kidney Injury
- #Immune Metabolism
- #Lipid Signaling
- ACOT8-mediated palmitate buildup in renal tubular cells during ischemia-reperfusion injury activates the cGAS-STING pathway in macrophages, driving them to a pro-inflammatory M1 state.
- Knockdown of ACOT8 in mice reduced palmitate accumulation, decreased M1 macrophage presence, lowered inflammation, and improved kidney function, highlighting ACOT8 as a treatment target.
- Multi-omics and machine learning identified ACOT8 among key genes linked to acute kidney injury, with its expression correlating with M1 macrophage infiltration in damaged kidneys.