Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4 - PubMed
3 hours ago
- #Cardiovascular-Kidney-Metabolic Syndrome
- #Mortality risk
- #Triglyceride-glucose index
- The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance (IR).
- Higher TyG levels are linked to increased cardiovascular risk in early-stage CKM, but its role in CKM stage 4 was unclear.
- A retrospective study analyzed 3,125 critically ill CKM stage 4 patients from the MIMIC-IV database.
- Patients were categorized into TyG index tertiles, with 1-year mortality rates of 28.79% (Q1), 35.06% (Q2), and 38.68% (Q3).
- Each 1-standard deviation increase in TyG index was associated with a 23% higher risk of 1-year mortality.
- Patients in the highest TyG tertile (Q3) had a 30% higher mortality risk compared to the lowest tertile (Q1).
- A linear positive relationship was found between TyG index and mortality.
- Higher TyG levels independently predict increased short- and long-term mortality in CKM stage 4 patients.
- The TyG index may aid in early risk stratification but requires further prospective validation for clinical use.