Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials - PubMed
3 hours ago
- #PCOS
- #Inositol
- #Meta-analysis
- Inositol shows significant benefits for women with PCOS, improving hormonal profiles, glycolipid metabolism, and reproductive outcomes.
- Quality assessments (AMSTAR-2 and GRADE) indicate most evidence is of low to very low quality, with no high-quality evidence found.
- Inositol reduces LH, total and free testosterone, and improves SHBG and androstenedione levels.
- Improvements in insulin resistance (HOMA-IR), fasting insulin, triglycerides, and reproductive outcomes like live births and ovulation rates were noted.
- Compared to metformin, inositol's effects were mostly non-significant except for triglycerides and pregnancy rates.
- Different inositol subtypes show varied efficacy; MI/MI+FA is superior for metabolic and reproductive outcomes, while D-chiro-inositol monotherapy requires caution.
- The study highlights the need for larger, rigorous trials to confirm findings based on low-quality evidence.