Long Non-Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin - PubMed
3 hours ago
- #STAT3
- #lncRNA H19
- #Systemic Sclerosis
- Long Non-Coding RNA H19 is highly upregulated in Systemic Sclerosis (SSc) skin and fibroblasts compared to healthy controls.
- H19 knockdown in SSc fibroblasts reduces profibrotic gene expression and cell contraction ability, while its overexpression induces a profibrotic phenotype in healthy fibroblasts.
- TGF-β, IL-6, and IL-11 increase H19 expression in fibroblasts via STAT3 activation.
- H19 mediates STAT3-dependent activation of both fibroblasts and keratinocytes in SSc, suggesting its role as a therapeutic target for fibrosis.