Reversible one-way lipid transfer at ER-autophagosome membrane contact sites via Atg2 - PubMed
12 hours ago
- #lipid transfer
- #membrane contact sites
- #autophagy
- Atg2 is a bridge-like lipid transfer protein (LTP) essential for autophagosome formation.
- The study used octadecyl rhodamine B (R18) to monitor phospholipid dynamics in vivo.
- Phospholipid transfer from the ER to the isolation membrane (IM) during autophagy was demonstrated.
- Reversible phospholipid flow from the IM back to the ER was observed upon autophagy termination.
- The findings emphasize the role of bridge-like LTPs in membrane contact site (MCS)-mediated phospholipid homeostasis.