Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau - PubMed
4 hours ago
- #Alzheimer's Disease
- #Epigenomics
- #Tauopathy
- Study focuses on the epigenomic landscape of Alzheimer's Disease (AD) brains, particularly oligodendrocyte molecular perturbations linked to tau.
- An epigenome-wide association study was conducted on DNA methylation in 472 AD brains, identifying 5478 significant associations, mostly with tau biochemical measures.
- Transcriptome-methylome integration shows enrichment in oligodendrocyte genes, including AD risk gene BIN1, myelination genes MYRF, MBP, MAG, and novel gene LDB3.
- Findings suggest tau-related oligodendrocyte gene perturbations as a common pathomechanism across tauopathies.
- Results are shared via the Multiomic Atlas, providing a resource for further research.