Enhanced dynamic risk stratification of smoldering multiple myeloma - PubMed
4 hours ago
- #biomarkers
- #multiple myeloma
- #risk stratification
- PANGEA-SMM is a new risk stratification model for smoldering multiple myeloma (SMM) that outperforms existing models.
- The model uses four evolving biomarkers to predict progression to active multiple myeloma (MM) with high accuracy.
- Key biomarkers include M-protein increase ≥0.2 g dl-1, involved/uninvolved serum free light chain ratio increase ≥20, creatinine increase >25%, and hemoglobin decrease ≥1.5 g dl-1.
- PANGEA-SMM provides an easy-to-use, open-access tool for clinicians to assess risk in SMM patients.
- The study involved a large cohort of 2,344 patients from seven international centers.
- Several authors disclosed conflicts of interest, including advisory roles and research funding from pharmaceutical companies.