Oral colon targeted curcumin-based nanocomposite inulin hydrogel for alleviating intestinal inflammation and dysbiosis - PubMed
3 hours ago
- #IBD
- #Curcumin
- #Hydrogel
- Development of an antioxidant-functionalized curcumin-loaded nanocomposite inulin hydrogel for targeted IBD therapy.
- The system encapsulates curcumin within chitosan-coated PLGA nanoparticles, enhancing ROS-scavenging and cellular uptake.
- In a mouse model, the hydrogel prolonged intestinal retention of curcumin, reducing inflammation and restoring microbial diversity.
- Combines anti-inflammatory effects with gut microbiota regulation for colitis management.
- Ethical approvals were obtained for animal studies, with efforts to minimize suffering.