Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study - PubMed
6 hours ago
- #Cardiorenal Outcomes
- #Aldosterone Dysregulation
- #Hypertension
- The study investigated the association between renin-aldosterone profiles and cardiorenal outcomes in adults with hypertension using data from Danish health registries from 2017 to 2024.
- Higher aldosterone-to-renin ratio (ARR), elevated aldosterone levels, and low renin levels were linked to increased risks of rapid kidney function decline, kidney failure, and major adverse cardiovascular events (MACE).
- The risk of adverse outcomes, such as rapid kidney function decline, showed a continuous gradient with higher ARR levels, with adjusted hazard ratios ranging from 1.27 to 2.66 across ARR categories.
- Findings indicate that renin-independent aldosterone production in hypertension is associated with a higher risk of cardiorenal events, underscoring the need for clinical attention even below diagnostic thresholds for primary aldosteronism.