BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic lateral sclerosis - PubMed
4 days ago
- #ALS
- #neuroinflammation
- #BTK inhibitor
- BTK inhibition shows promise in suppressing neuroinflammation and neurodegeneration in ALS.
- ALS involves dysregulated cGAS-STING-NF-κB signaling, with BTK as a key regulator.
- Elevated BTK phosphorylation observed in ALS patient tissues and SOD1-mutant hiPSC models.
- BTK inhibition reduces DNA damage in motor neurons and restores microglial phagocytosis.
- In SOD1-G93A mice, BTK blockade extends survival and improves motor function.
- BTK integrates multiple pathogenic pathways, offering a therapeutic target for ALS.