Gastric disease in systemic sclerosis: Spectrum, challenges, and insights from a systematic literature review - PubMed
7 days ago
- #gastric disease
- #systemic sclerosis
- #medical review
- Gastric complications in systemic sclerosis (SSc) are common and clinically diverse but often overlooked.
- The review synthesizes evidence on prevalence, clinical relevance, and diagnostic strategies for gastric disease in SSc.
- Gastric dysmotility was frequent, with delayed emptying in 18-64% and bradygastria in 12-70%.
- Gastric antral vascular ectasia (GAVE) prevalence ranged from 0 to 22.3%.
- Mucosal abnormalities like gastritis, ulcers, and cancer were common but inconsistently defined.
- Helicobacter pylori prevalence varied widely (10-78%), with lower detection via biopsy or breath testing than serology.
- Associations between objective findings and patient-reported outcomes (PROs) were inconsistent and underexplored.
- Standardized diagnostics, validated PROs, and longitudinal studies are needed to improve care and research in SSc.