Hierarchically Targeted Cu-Doped Carbon Dot/Kynurenic Acid@RM Platform for Restoring Mitochondrial Metabolism and Modulating Inflammation in Acute Pancreatitis - PubMed
3 hours ago
- #nanotherapy
- #mitochondrial-dysfunction
- #acute-pancreatitis
- A hierarchically targeted nanotherapeutic, Cu-CDs/Kyna@RM (RMCK), is developed for treating acute pancreatitis (AP).
- RMCK consists of copper-doped carbon dots (Cu-CDs) grafted with kynurenic acid (Kyna) and encapsulated in red blood cell-macrophage hybrid membranes.
- The platform targets inflamed pancreatic tissue, scavenges ROS, and restores mitochondrial function.
- RMCK improves survival, reduces serum amylase/lipase levels, and prevents secondary lung injury in AP models.
- In vitro, RMCK decreases acinar cell injury and LDH release induced by sodium taurocholate (STC).
- Mechanistic studies show RMCK inhibits GPR35-NF-κB, prevents mtDNA-driven inflammasome activation, and restores fatty acid oxidation.
- The platform offers a versatile approach for inflammatory diseases with mitochondrial dysfunction.