Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury - PubMed
4 hours ago
- #ferroptosis
- #SIRT5
- #acute kidney injury
- The SIRT5-PRDX6 axis plays a regulatory role in sepsis-associated acute kidney injury (SA-AKI).
- Ferroptosis is identified as a key mechanism in the progression of SA-AKI.
- In LPS-induced models, markers of oxidative stress and inflammation increase, while protective factors like GPX4 and GSH decrease.
- SIRT5 levels decrease over time after LPS stimulation; its knockdown worsens ferroptosis, and its overexpression suppresses it.
- SIRT5 desuccinylates PRDX6 at lysine 209, inhibiting inflammatory and oxidative stress responses to attenuate ferroptosis.
- Targeting the SIRT5-PRDX6 axis could be a novel therapeutic strategy for SA-AKI.