Optimal Ablation Strategies for Persistent Atrial Fibrillation With Heart Failure: Three-Year Follow-Up of a Prospective Multicenter Randomized Trial - PubMed
4 hours ago
- #catheter ablation
- #atrial fibrillation
- #heart failure
- The study compared three catheter ablation strategies in 300 patients with persistent atrial fibrillation (AF) and heart failure (HF): anatomic-guided, electrogram-guided, and extensive electro-anatomic-guided ablation.
- After 36 months, extensive electro-anatomic-guided ablation showed the lowest incidence of cardiovascular death or HF-related hospitalization (17%) and the highest rate of sinus rhythm maintenance (62%).
- Secondary outcomes, including AF burden <1%, symptom improvement, and NT-proBNP reduction, favored the extensive electro-anatomic-guided approach, with low and similar complication rates across groups.
- Benefits were consistent across both HF with reduced ejection fraction and HF with preserved ejection fraction subgroups.