Molecular insights into antimicrobial resistance and virulence in hospital-associated of vancomycin-resistant Enterococcus faecium isolates in a tertiary hospital in Bangkok Thailand - PubMed
6 hours ago
- #antimicrobial resistance
- #virulence factors
- #VREfm
- The study analyzed 52 clinical VREfm isolates from Bangkok hospitals between June and November 2022, focusing on genetic characteristics.
- All isolates were resistant to penicillin, ampicillin, vancomycin, levofloxacin, ciprofloxacin, and rifampin, with additional resistance to erythromycin (98.1%), high-level streptomycin (53.8%), teicoplanin (51.9%), and tetracycline (17.3%).
- The vanA gene was the only vancomycin resistance determinant detected, and virulence genes esp and hyl were present in 100% and 88.5% of isolates, respectively.
- MLST identified five sequence types, with ST17 dominant (86.5%), and all isolates belonged to Clonal Complex 17.
- Genome analysis revealed various resistance genes and virulence factors, highlighting the role of mobile genetic elements in driving antimicrobial resistance and adaptation in hospital settings.