Comparative analysis of microbial diversity and clinical outcomes in critically ill patients with and without malignancies: a single-center retrospective cohort study - PubMed
5 hours ago
- #septic shock
- #metagenomics
- #microbial diversity
- Study compares microbial diversity and clinical outcomes in critically ill patients with and without malignancies.
- 107 septic shock patients (52 cancer, 55 non-cancer) analyzed using multi-site metagenomic next-generation sequencing (mNGS).
- Cancer patients were older with higher comorbidity scores but had lower pathogen detection rates and shorter ICU stays.
- Dominant pathogens included Klebsiella pneumoniae and Enterococcus faecium with diverse antibiotic resistance genes (ARGs).
- IL-6 identified as a significant prognostic indicator for cancer patients.
- mNGS provides valuable insights for targeted antimicrobial strategies and prognostic stratification in cancer patients.