Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation-a controlled study - PubMed
3 hours ago
- #Long-COVID
- #Neuroinflammation
- #Systemic inflammation
- Long-COVID study finds no evidence of cerebral neuronal damage or neuroinflammation.
- No significant differences in neurofilament light (NfL) or glial fibrillary acidic protein (GFAP) between long-COVID patients and controls.
- Ultrasensitive assays showed nominally elevated levels of CRP, TNF-α, IL-6, and TREM2 in long-COVID patients, but differences did not survive correction for multiple comparisons.
- Findings suggest persistent long-COVID symptoms may not be due to ongoing neuronal injury or CNS inflammation.
- Study highlights the need for larger, longitudinal cohorts to validate these preliminary findings.