Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease - PubMed

9 hours ago

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and accumulation of amyloid beta plaques and tau tangles.
Autophagy, a cellular degradation process, is crucial for neuronal health and is impaired in AD, making it a potential therapeutic target.
Lifestyle factors such as diet (intermittent fasting, calorie restriction), physical activity, and adequate sleep can positively influence autophagy and support cognitive function.
Intermittent fasting and calorie restriction activate autophagy and promote longevity.
Physical activity enhances cerebral blood flow and neurotrophic signaling, benefiting brain health.
Adequate sleep supports autophagic processes, while sleep deprivation disrupts them.
Excessive autophagy may be detrimental, highlighting the need for balanced regulation.
Understanding how lifestyle modulates autophagy is essential for developing non-pharmacological strategies to delay or prevent AD.

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