Decoding lung-kidney interactions in sepsis: an integrated view of molecular mechanisms, pathophysiology, and therapeutic interventions - PubMed
3 days ago
- #organ crosstalk
- #sepsis
- #therapeutic interventions
- Sepsis is a global health concern with high mortality and multi-organ dysfunction, particularly affecting the lung and kidney.
- Lung-kidney interactions in sepsis involve molecular mechanisms, pathophysiology, and therapeutic interventions.
- Dysfunction in one organ (lung or kidney) can exacerbate injury in the other, increasing sepsis mortality.
- Cytokines, inflammatory mediators, and bioactive substances (e.g., lipocalin-2, α-klotho, osteopontin) contribute to immune dysregulation and distant tissue injury.
- Kidney injury leads to water-sodium imbalance, acid-base disturbances, and oxidative stress, worsening respiratory distress.
- Lung injury causes hypoxemia, hypercapnia, hemodynamic changes, and endothelial injury, reducing glomerular filtration rate.
- Mechanical ventilation and renal replacement therapy further complicate lung-kidney interactions in sepsis.
- Preclinical studies suggest potential therapeutic targets, but clinical validation is lacking.
- Future research should explore organ-organ axes, molecular landscapes, and precise models (e.g., organ chips) for better intervention strategies.