Mechanism of cancer-associated fibroblast-driven thyroid cancer dedifferentiation via the ZFP57-PKM2 axis-mediated lactate secretion and therapeutic intervention with resveratrol - PubMed
3 hours ago
- #Cancer-associated fibroblasts
- #Thyroid cancer
- #Resveratrol
- The study explores the mechanism by which cancer-associated fibroblasts (CAFs) drive thyroid cancer dedifferentiation through the ZFP57-PKM2 axis-mediated lactate secretion.
- Resveratrol is identified as a potential therapeutic intervention for this process.
- The research utilizes spatial transcriptomics to investigate glycolysis in papillary thyroid carcinoma.
- All animal procedures were ethically approved by the Animal Care and Use Ethics Committee of China Medical University.
- The study received funding from multiple Liaoning Provincial Science and Technology Joint Programs and other grants.