Aryl hydrocarbon receptor is critical for both AR-dependent and AR-indifferent enzalutamide resistance in castration-resistant prostate cancer - PubMed
4 hours ago
- #AHR
- #prostate cancer
- #enzalutamide resistance
- Aryl hydrocarbon receptor (AHR) plays a critical role in enzalutamide (ENZ) resistance in castration-resistant prostate cancer (CRPC).
- AHR is upregulated in ENZ-resistant CRPC cell lines and high-grade prostate tumors from ENZ-treated patients.
- Knockdown of AHR reduces growth of ENZ-resistant CRPC cells and xenografts.
- AHR operates through distinct mechanisms: AR-dependent (regulating AR/GR co-target genes) and AR-indifferent (promoting neuroendocrine differentiation).
- Findings suggest AHR as a potential therapeutic target for ARSI-resistant advanced prostate cancer.