A lineage-specific selective autophagy receptor module mediates P-body turnover - PubMed
4 hours ago
- #selective autophagy
- #α-synuclein degradation
- #P-body turnover
- A lineage-specific selective autophagy receptor module mediates P-body turnover in Marchantia polymorpha.
- Conserved decapping proteins EDC4 and DCP1 act as a selective autophagy receptor pair for P-body degradation.
- MpEDC4 binds ATG8 via a canonical motif, while MpDCP1 uses a reverse ATG8-interacting motif in its disordered region.
- Mutations in these motifs impair P-body autophagic degradation, showing a cooperative receptor mechanism.
- This autophagic function is lineage-specific, absent in Arabidopsis and human orthologs.
- Heterologous expression of MpEDC4 in human cells promotes degradation of α-synuclein, linked to Parkinson's disease.
- Findings link RNA metabolism to selective autophagy and enable cross-kingdom engineering of protein degradation pathways.