Current state of CAR-T cell therapies for solid tumors - PubMed
4 days ago
- #immunotherapy
- #CAR-T cells
- #solid tumors
- CAR-T cell therapy has revolutionized treatment for hematological malignancies but faces challenges in solid tumors.
- Key challenges include tumor antigen heterogeneity and the immunosuppressive tumor microenvironment.
- Strategies to improve CAR-T cell efficacy in solid tumors include multi-antigen targeting and combination therapies.
- Armored CAR-T cells and synthetic engineering are among the innovative approaches being explored.
- Ongoing research is crucial to overcome existing limitations and expand CAR-T therapy to solid tumors.