Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK - PubMed
4 hours ago
- #Lipogenesis
- #MASLD
- #PIEZO1
- PIEZO1, a mechanosensitive ion channel, is found in hepatocytes and downregulated in MASLD patients and high-fat diet-induced mouse models.
- Hepatocyte-specific deletion of Piezo1 in mice exacerbates triglyceride accumulation and upregulates de novo lipogenesis genes while reducing AMPK and RAPTOR phosphorylation.
- Activation of PIEZO1 with Yoda1 alleviates triglyceride buildup, downregulates lipogenesis genes, and enhances AMPK and RAPTOR phosphorylation in mice and HepG2 cells.
- PIEZO1 responds to membrane tension changes and activates AMPK, which inhibits lipogenesis, helping maintain lipid homeostasis and ameliorate MASLD.