Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in Drosophila - PubMed
7 hours ago
- #ether phospholipids
- #somatosensation
- #Drosophila
- Ether phospholipids (ePLs) enhance PIEZO activation and mechanosensory responses in Drosophila.
- Reduced ePL synthesis leads to diminished mechanosensory behavior in PIEZO-expressing neurons.
- ePLs modulate thermosensory behavior and lower the temperature threshold for TRPA1 channels.
- ePLs affect membrane tension and lipid order in the plasma membrane of cultured cells.
- The study highlights ePLs as modulators of multiple somatosensory receptors via membrane lipid-protein interactions.