PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2 - PubMed
4 hours ago
- #metastasis
- #prostate cancer
- #ferroptosis
- PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer cells.
- Nuclear PDHA1 increases H3K9Ac at the PPARA promoter, upregulating PPARA and AIFM2 expression.
- AIFM2 upregulation inhibits ferroptosis, promoting survival and metastasis of prostate cancer cells.
- PDHA1 is elevated in metastatic prostate cancer patients, suggesting a therapeutic target.