Bi-Target Nanomodulator for Glioma-Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH-Mutant Gliomas
4 hours ago
- #immunotherapy
- #nanomodulator
- #glioma
- A bi-target nanomodulator (LCC@GMM) is developed to enhance immunotherapy for IDH-mutant gliomas.
- The nanomodulator uses a hybrid glioma-macrophage cell membrane for BBB penetration and dual homing to tumor cells and GAM.
- It induces pyroptosis in tumor cells via ROS and La3+ release and regulates tryptophan metabolism in GAM via an AhR antagonist (CH223191).
- This approach overcomes the immunosuppressive effects of IDH-mutant gliomas by reshaping the tumor microenvironment.
- The study offers a novel strategy for immunotherapy targeting IDH-mutant gliomas.