C/EBPβ dictates postmenopausal FSHβ transcription and blockade of AEP/C/EBPβ pathway alleviates osteoporosis - PubMed
3 hours ago
- #osteoporosis
- #FSH
- #C/EBPβ
- FSH (Follicle-stimulating hormone) increases in post-menopausal females, leading to bone loss by activating osteoclasts.
- C/EBPβ is identified as a transcription factor for the fshb gene, directly binding to its promoter and regulating FSHβ mRNA transcription in the pituitary gland.
- Knocking down C/EBPβ reduces GnRH-induced FSHβ expression in primary pituitary cells and lowers FSHβ levels in mice.
- Inactivation of AEP (asparagine endopeptidase) suppresses C/EBPβ activity, reducing FSHβ levels and alleviating osteoporosis caused by ovariectomy (OVX).
- A specific AEP inhibitor (#11a) shows therapeutic effects comparable to the FDA-approved drug teriparatide in treating OVX-induced osteoporosis.