Long-Term Prospective Cohort Study of Cervical Cancer Screening Using Triage of Women who Are Human Papillomavirus-Positive With Dual Stain and Human Papillomavirus Genotyping - PubMed
3 days ago
- #HPV screening
- #dual stain
- #cervical cancer
- Study evaluates triage methods for HPV-positive women in cervical cancer screening.
- Dual stain (DS) and HPV genotyping compared to cytology for detecting CIN3+.
- DS showed better sensitivity, specificity, and predictive values than cytology over 5 years.
- Baseline CIN3+ risk: 9.4% for DS-positive vs. 0.8% for DS-negative.
- HPV16-positive women had higher CIN3+ risk than HPV16-negative.
- DS outperformed cytology across all age groups and non-HPV16/18 types.
- DS detects molecular changes earlier in the carcinogenic pathway than cytology.
- DS provides better risk stratification, making it suitable for vaccinated populations.