Stomach at the Crossroads: Nuclear Receptor Signaling at the Interface Between What We Are and What We Eat - PubMed
4 hours ago
- #Gastric Homeostasis
- #Nuclear Receptor Signaling
- #Dietary Compounds
- The stomach contains nuclear receptor transcription factors (NRs) that respond to food, toxins, and ingested agents.
- NRs play a role in gastric homeostasis, development, cell fate determination, and responses to dietary compounds and xenobiotics.
- The stomach is among the first organs to encounter dietary compounds and pollutants, making NR signaling crucial.
- NRs contribute to pathological conditions such as precancerous lesions and gastric cancer.
- The review explores gastro-endocrinology, focusing on how systemic endocrine circuits influence stomach function.
- Potential therapeutic targets include known NR agonists, antagonists, and co-regulatory proteins.
- Understanding NR roles could improve treatments for gastritis, gastric intestinal metaplasia, and gastric cancer.