Molecular Epidemiology and Persistence of Multidrug-Resistant Acinetobacter baumannii in Zhejiang, China (2015-2020): Insights Into Resistance, Virulence, and Transmission Dynamics - PubMed
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- #Acinetobacter baumannii
- #Molecular epidemiology
- #Antimicrobial resistance
- Study on 184 Acinetobacter baumannii clinical isolates in Zhejiang, China (2015-2020).
- 78.8% of isolates showed carbapenem resistance, primarily due to blaOXA-23, blaOXA-72, blaOXA-58, and blaNDM-1.
- Population divided into 2 clusters based on ST types and resistance islands profiles.
- Cluster2 involved 71 department-time transmission events, mainly in rehabilitation medicine and ICU.
- Recombination mainly occurred in capsular locus (KL) regions, prophage regions, and predicted protein regions.
- ST208-KL2 isolates showed increased virulence and serum resistance compared to ST208-KL7.
- ST208-KL2 emerged as a dominant lineage with global implications for infection control.