Combination Disease-Modifying Therapy for Neurodegenerative Diseases Using Repurposed Drugs - PubMed
5 hours ago
- #combination therapy
- #neurodegenerative diseases
- #drug repurposing
- Explores the positive effects of repurposed drugs in preclinical models and human data for neurodegenerative diseases.
- Drugs include chemical chaperones, GLP-1 receptor agonists, iron chelators, and c-Abl tyrosine kinase inhibitors.
- Focuses on Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease.
- Introduces a combinatory neuroprotective therapy approach using drug repurposing.
- Proposes a strategy to design drug combinations addressing multiple pathogenic processes for meaningful clinical results.