A microbiota-tryptophol-AhR axis mediates the gut-kidney protective effects of Hushen Tongfengtai Granules in hyperuricemic nephropathy - PubMed
3 hours ago
- #gut microbiota
- #aryl hydrocarbon receptor
- #hyperuricemic nephropathy
- Hushen Tongfengtai Granules (HSTFT) alleviate hyperuricemic nephropathy by improving renal injury and intestinal barrier dysfunction.
- The therapeutic effects are gut microbiota-dependent, linked to enrichment of Bifidobacterium breve.
- Tryptophol (TOL) is identified as a key metabolite; it mimics HSTFT's protective effects by activating the aryl hydrocarbon receptor (AhR) pathway.