Olfactomedin 1 acts as a tumor suppressor in glioblastoma: integrated analysis and mechanistic prediction - PubMed
4 hours ago
- #Glioblastoma
- #Tumor Suppressor
- #JAK-STAT3
- Olfactomedin 1 (OLFM1) acts as a tumor suppressor in glioblastoma (GBM).
- High OLFM1 expression predicts better survival in GBM patients.
- OLFM1 inhibits macrophage polarization from M0 to M2 phenotype.
- OLFM1 downregulates the JAK-STAT3 signaling pathway.
- Rosuvastatin is identified as a potential OLFM1-related GBM inhibitor.
- OLFM1 is a potential prognostic biomarker and therapeutic target for GBM.