IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome - PubMed
7 hours ago
- #PCOS
- #Endometrial Receptivity
- #IGFBP5
- PCOS affects 5-18% of reproductive-age women globally, leading to infertility.
- The IL-22-STAT3 pathway's downregulation impairs endometrial receptivity in PCOS.
- Exogenous IL-22 administration in PCOS-like mice restored STAT3 phosphorylation and improved implantation.
- IGFBP5 was identified as a STAT3 downstream target in endometrial organoids from PCOS patients.
- IGFBP5 knockdown negated IL-22's benefits, while supplementation restored endometrial receptivity in PCOS-like mice.
- The IL-22-STAT3-IGFBP5 axis suppression is key to PCOS-related endometrial receptivity issues.
- IGFBP5 supplementation emerges as a potential therapy for improving pregnancy outcomes in PCOS.